High Quality Factory Pterostilbene CAS NO 537-42-8

High Quality Factory Pterostilbene CAS NO 537-42-8

Basic Information:

Product Name: Pterostilbene

Other Name: 3',5'-Dimethoxy-4-stilbenol; 3,5-Dimethoxy-4'-hydroxy-E-stilbene

Molecular Weight: 256.301 

Molecular Formula: C16H16O3

CAS NO: 537-42-8

Purity:≥99.0%

Appearance: White crystalline powder, soluble in alcohol, sealed at low temperature and protected from light.

Functions:

Pterostilbene is considered to be a corrosive substance, is dangerous upon exposure to the eyes, and is an environmental toxin, especially to aquatic life.

Its chemical relative, resveratrol, received FDA GRAS status in 2007, and approval of synthetic resveratrol as a safe compound by the European Food Safety Authority (EFSA) in 2016. Pterostilbene differs from resveratrol by exhibiting increased bioavailability (80% compared to 20% in resveratrol) due to the presence of two methoxy groups which cause it to exhibit increased lipophilic and oral absorption.

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a naturally derived compound found primarily in blueberries and Pterocarpus marsupium (PM) heartwood. The amount of daily pterostilbene consumption varies according to dietary fruit intake, and it has been estimated that pterostilbene content per blueberry varies from 99 ng to 520 ng/gram depending on the type of berry ingested. Substantial evidence suggests that pterostilbene may have numerous preventive and therapeutic properties in a vast range of human diseases that include neurological, cardiovascular, metabolic, and hematologic disorders. Further benefits of pterostilbene have been reported in preclinical trials, in which pterostilbene was shown to be a potent anticancer agent in several malignancies. Pterostilbene is structurally similar to resveratrol, a compound found in red wine that has comparable antioxidant, anti-inflammatory, and anticarcinogenic properties; however, pterostilbene exhibits increased bioavailability due to the presence of two methoxy groups which cause it to exhibit increased lipophilic and oral absorption . In animal studies, pterostilbene was shown to have 80% bioavailability compared to 20% for resveratrol making it potentially advantageous as a therapeutic agent .

The multiple benefits of pterostilbene in the treatment and prevention of human disease have been attributed to its antioxidant, anti-inflammatory, and anticarcinogenic properties leading to improved function of normal cells and inhibition of malignant cells. Treatments with blueberry extract and PM in similar disease models have yielded paralleled results possibly due to the antioxidant activity and underlying mechanisms of pterostilbene. The evidence presented in this review shows that pterostilbene reduces oxidative stress (OS) and production of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2) and superoxide anion (O2 −), which are implicated in the initiation and pathogenesis of several disease processes.

Usage: Pharmaceutical Intermediates

Certificate of Analysis: