High Quality Factory Pterostilbene CAS NO 537-42-8

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Product Details

High Quality Factory Pterostilbene CAS NO 537-42-8

Basic Information:

Product Name: Pterostilbene

Other Name: 3',5'-Dimethoxy-4-stilbenol; 3,5-Dimethoxy-4'-hydroxy-E-stilbene

Molecular Weight: 256.301 

Molecular Formula: C16H16O3

CAS NO: 537-42-8

Purity:≥99.0%

Appearance: White crystalline powder, soluble in alcohol, sealed at low temperature and protected from light.


Functions:

Pterostilbene is considered to be a corrosive substance, is dangerous upon exposure to the eyes, and is an environmental toxin, especially to aquatic life.

Its chemical relative, resveratrol, received FDA GRAS status in 2007, and approval of synthetic resveratrol as a safe compound by the European Food Safety Authority (EFSA) in 2016. Pterostilbene differs from resveratrol by exhibiting increased bioavailability (80% compared to 20% in resveratrol) due to the presence of two methoxy groups which cause it to exhibit increased lipophilic and oral absorption.

Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene) is a naturally derived compound found primarily in blueberries and Pterocarpus marsupium (PM) heartwood. The amount of daily pterostilbene consumption varies according to dietary fruit intake, and it has been estimated that pterostilbene content per blueberry varies from 99 ng to 520 ng/gram depending on the type of berry ingested. Substantial evidence suggests that pterostilbene may have numerous preventive and therapeutic properties in a vast range of human diseases that include neurological, cardiovascular, metabolic, and hematologic disorders. Further benefits of pterostilbene have been reported in preclinical trials, in which pterostilbene was shown to be a potent anticancer agent in several malignancies. Pterostilbene is structurally similar to resveratrol, a compound found in red wine that has comparable antioxidant, anti-inflammatory, and anticarcinogenic properties; however, pterostilbene exhibits increased bioavailability due to the presence of two methoxy groups which cause it to exhibit increased lipophilic and oral absorption . In animal studies, pterostilbene was shown to have 80% bioavailability compared to 20% for resveratrol making it potentially advantageous as a therapeutic agent .

The multiple benefits of pterostilbene in the treatment and prevention of human disease have been attributed to its antioxidant, anti-inflammatory, and anticarcinogenic properties leading to improved function of normal cells and inhibition of malignant cells. Treatments with blueberry extract and PM in similar disease models have yielded paralleled results possibly due to the antioxidant activity and underlying mechanisms of pterostilbene. The evidence presented in this review shows that pterostilbene reduces oxidative stress (OS) and production of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2) and superoxide anion (O2 −), which are implicated in the initiation and pathogenesis of several disease processes.

Usage: Pharmaceutical Intermediates

 

Certificate of Analysis:

Basic information

Product Name

Pterostilbene

Structure

图片2

CAS No.

537-42-8

Molecular formula

C16H16O3

Molecular weight

256.30

EINECS

227-804-6

Batch Number

SH200714

Date of Certificate

April 25th, 2020

Standard Item

Specification

Test Results

Appearance

White Crystalline Powder

Confirm

Identification

A.H-NMR:Comply with the structure

Complies

B.LC-MS:Comply with the structure

Complies

C.The IR spectrum of sample should be identical with that of reference standard;

Complies

D.HPLC-ESI-MS

The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.

Complies

Crystallinity

Meets the requirements.

Complies

Loss on drying

1.0%

0.85%

Heavy metals

≤10 ppm

<10ppm

Water

≤1.0%

0.1%

Sulphated ash

≤0.5%, determined on 1.0 g.

0.009%

Related substances

Unspecified impurities: for each impurity

≤0.10%

<0.10%

Total Impurity

≤0.5%

0.18%

Mass

203.67±1

Conforms

NMR

Comply with the structure

Conforms

Purity

≥99.0%

99.29%

Assay

99.0%~101.0% (anhydrous substance).

99.63%

Microbiological Analysis

Total plate count

≤1000cfu/g

Complies

Yeast and Moulds

≤100cfu/g

Complies

E. Coli.

Absent

Negative

Salmonella

Absent

Negative

S.aureus

Absent

Negative

Storage

Preserve in well-closed, light-resistant and airtight containers.

Retest date

Two years under conditions list above

Conclusion

Conform with Conform with specification


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