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benflumetol, a novel antimalarial compound belonging to the fluorenes (2,3-benzindenes), has high blood schizontocidal activity, in vitro and in vivo, against mammalian plasmodia, including chloroquine-resistant Plasmodium falciparum. Due to its molecular structure benflumetol occurs in the dextrorotatory and the laevorotatory form. Normal synthesis yields the racemate of both enantiomers. Enantiomers of some antimalarial drugs possess different specific activity. It was therefore of interest to compare the response of P. falciparum to the enantiomers and the racemate of benflumetol in a variety of fresh, natural isolates. Measuring the concentration-specific inhibition of schizont maturation, the parallel investigation of 29 isolates produced no evidence of substantial activity differences between (+)-benflumetol, (−)-benflumetol and racemic benflumetol, the mean EC-50 values being 8.87, 9.71 and 12.44 nmol/l blood-medium-mixture, respectively.



Product Name:Lumefantrine

Appearance:Yellow powder


Molecular formula:C30H32Cl3NO

Molecular weight:528.94018

Test Method:HPLC

Shelf Life:2 Years

Melting point:129-131°C



Lumefantrine (benflumetol)  is a new kinds of mefloquine drug. 

Obvious Effect of killing vivax malaria, as well as in preventing.

It also can kill the Falciparum malaria phorozoon, but slow effect.

It can reduce the gametophyte rate in blood, suppression the development of the gametophyte in mosquitoes.

The cure rate of chloroquine-resistant and multidrug-resistant falciparum malaria is more than 95%.

Animal experiments show that the toxicity of this product is very low, and no adverse reaction on the clinical.

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