Anti Cancer Herbs Tanshinone I With Best Price

Anti Cancer Herbs Tanshinone I With Best Price

Our products have high purity and solubility. We have big supply of our products.All products are well stocked. Prompt delivery is available.

Chat Now

Product Details

抬头2.png

1-product details.jpg

Product name: Tanshinones

Active ingredient: Tanshinones

Botanical source: Salvia miltiorrhiza Bunge

Biogenic origin: Wild in central and southern China

CAS NO.: 568-73-0

Specification: 97%

Molecular formula: C18H12O3

Molecular Weight: 276.29

Characters: red fine powder

Solubility: Easily soluble in methanol; soluble5mg/ml

Usage: Pharmaceuticals, healthcares

2-product description.jpg

Tanshinones are the major bioactive compounds of Salvia miltiorrhiza Bunge (Danshen) roots, which are used in many therapeutic remedies in Chinese traditional medicine. We investigated the anticancer effects of tanshinones on the highly invasive human lung adenocarcinoma cell line, CL1-5. Tanshinone I significantly inhibited migration, invasion, and gelatinase activity in macrophage-conditioned medium-stimulated CL1-5 cells in vitro and also reduced the tumorigenesis and metastasis in CL1-5-bearing severe combined immunodeficient mice. Unlike tanshinone IIA, which induces cell apoptosis, tanshinone I did not have direct cytotoxicity. Real-time quantitative PCR, luciferase reporter assay, and electrophoretic mobility shift assay revealed that tanshinone I reduces the transcriptional activity of interleukin-8, the angiogenic factor involved in cancer metastasis, by attenuating the DNA-binding activity of activator protein-1 and nuclear factor-kappaB in conditioned medium-stimulated CL1-5 cells. Microarray and pathway analysis of tumor-related genes identified the differentially expressed genes responding to tanshinone I, which may be associated with the Ras-mitogen-activated protein kinase and Rac1 signaling pathways. These results suggest that tanshinone I exhibits anticancer effects both in vitro and in vivo and that these effects are mediated at least partly through the interleukin-8, Ras-mitogen-activated protein kinase, and Rac1 signaling pathways. 

 

3-product analysis.jpg

Item

  Specification

  Result

  Method

BasicProduct Information

Product name

Tanshinone I



Part of the Plant

root

Conform

/

Country of Origin

China

Conform

/

Organoleptic Data

Appearance

Fine powder

Conform

NLS-QCS-1008

Color

red Powder

Conform

GB/T 5492-2008

Odor& Taste

Characteristic

Conform

GB/T 5492-2008

Process Data

Solvent(s) Used

Water and ethyl alcohol

Conform

/

Extract ration

10:1

Conform


Content

/

/


Drying Method

Spray drying

Conform

/

Excipient

Maltodextrin 

Conform

/

Physical Characteristics

Particle Size (80 mesh)

98.0%pass 80mesh

Conform

GB/T 5507-2008

Moisture

<5.0%

2.8%

GB/T 14769-1993

Ash Content

<4.0%

1.4%

AOAC 942.05, 18th

Solvent Residue

Eur. Pharm

Conform

NLS-QCS-1007

Heavy Metals

Total Heavy Metals

<10 ppm

Conform

USP <231>, method II

Arsenic

<1.0 ppm

Conform

AOAC 986.15, 18th

Lead

<1.0 ppm

Conform

AOAC 986.15, 18th

Mercury

<0.5 ppm

Conform

AOAC 971.21, 18th

Pesticide Residue

666

<0.2ppm

Conform

GB/T5009.19-1996

DDT

<0.2ppm

Conform

GB/T5009.19-1996

Microbiology

Total Plate Count

<1,000cfu/g

17cfu/g

AOAC 990.12, 18th

Total Yeast & Mold

<100cfu/g

3cfu/g

FDA (BAM) Chapter 18, 8th Ed.

E. Coli

Negative

Negative

AOAC 997.11, 18th

Salmonella

Negative

Negative

FDA (BAM) Chapter 5, 8th Ed.

4-product function.jpg

Danshen (Salvia miltiorrhiza Bunge) is a herb that has been widely and successfully used for treating inflammatory diseases in clinics in Asia. The relatively abundant tanshinones, tanshinone I, tanshinone IIA, cryptotanshinone, and dihydrotanshinone, have been isolated from Danshen. These tanshinones are the major diterpenes isolated from Danshen, and show cytotoxic effects on cell lines derived from human carcinomas of the colon, ovary, lung, mouth, and breast. Recently, anti-cancer activities of tanshinone IIA have been reported, which suggest that the structurally similar tanshinone I may possess similar cytotoxic effects on tumor cells. We investigated the effect of tanshinone I on the induction of apoptosis in human breast cancer cells (MCF-7 and MDA-MB-231) in vitro. Tanshinone I inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose- and time-dependent manner, as assayed by MTT. In addition, TUNEL assay and flow cytometry showed that tanshinone I significantly induced apoptosis in MCF-7 and MDA-MB-231 cells. The induction of apoptotic cell death was mediated by the activation of caspase 3, the downregulation of the level of the anti-apoptotic protein, Bcl-2, and the upregulation of the level of the pro-apoptotic protein, Bax. Taken together, these results reveal a potential mechanism for the anti-cancer effect of tanshinone I on human breast cancer cells, and suggest that tanshinone I may serve as an effective adjunctive reagent in the treatment of human breast cancer.


06.jpg


包装.jpg

加工过程.jpg

证书.jpg

If you need our products, PLS feel free to contact us. We will supply superior quality product and best service for you.   http://www.bgherbalextract.com/contact-us

Previous:Anti Cancer Medicine Eucommia Ulmoides Extract Next:Hot Sale Rhubarb Root Extract For Natural Pigment

Inquiry