Pure Extract Of Peganum Harmala

Pure Extract Of Peganum Harmala

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Product Details

1-product details

Detailed Product Description

Product name: Harmine

Source:Peganum harmala L.

Specification:98%

Used Part:Seed

CAS NO. :442-51-3
Molar mass:212.2472

Melting range:262-264°C

Flash Point(°C):139.7°

Appearance:White powder

Flavor: Characteristic taste

Particle Size:80% pass through 80 mesh sieve

Test mothed: HPLC

Molecular formula:C13H12N2O
Extract Solvent: Ethanol & Water

Solubility: Solubility in Methanol. Water-insoluble

Usage: Pharmaceuticals, healthcares,and cosmetics

2-product description

Harmine, and plants containing significant amounts of harmine and other harmala alkaloids are generally not considered safe treatments for depression within the medical community. This bias however is primarily built on previous decades of experience with pharmaceutical non-specific MAOIs that block both MAO-A and MAO-B. Inhibiting MAO-A or MAO-B (in high enough doses) while consuming foods rich in tyramine, e.g. cheese, can cause tyramine, ordinarily metabolized by these enzymes, to accumulate to dangerous levels. This can cause a potentially fatal hypertensive crisis. Because harmine reversibly and selectively inhibits MAO-A and does not degrade MAO-B, MAO-B remains free to metabolize tyramine in the digestive tract. Consequently, the harmala alkaloids (including harmine) are unlikely to elicit tyramine-mediated hypertensive crisis, and a special diet does not need to be so strictly adhered to. Nonetheless, due to the reduction of the levels of tyramine degrading compounds in the gut, it is still not advisable to eat excessively large amounts of tyramine-rich food products.[8] The reversibility and MAO-A selectivity of harmala alkaloids do not, however, prevent potentially fatal interactions with common medications such as antihistamines, most antidepressants, many stimulants, common migraine medications, some herbs, decongestants, expectorants, and common cough and cold medications.

3-product analysis

Item

  Specification

  Result

  Method

BasicProduct Information

Product name

pure extract of peganum harmala



Part of the Plant

seed

Conform

/

Country of Origin

China

Conform

/

Organoleptic Data

Appearance

Fine powder

Conform

NLS-QCS-1008

Color

white powder

Conform

GB/T 5492-2008

Odor& Taste

Characteristic

Conform

GB/T 5492-2008

Process Data

Solvent(s) Used

Water and ethyl alcohol

Conform

/

Extract ration

/

Conform


Content

Paeoniflorin98%

98.19


Drying Method

Spray drying

Conform

/

Excipient

Maltodextrin 

Conform

/

Physical Characteristics

Particle Size (80 mesh)

98.0%pass 80mesh

Conform

GB/T 5507-2008

Moisture

<5.0%

2.8%

GB/T 14769-1993

Ash Content

<4.0%

1.5%

AOAC 942.05, 18th

Solvent Residue

Eur. Pharm

Conform

NLS-QCS-1007

Heavy Metals

Total Heavy Metals

<10 ppm

Conform

USP <231>, method II

Arsenic

<1.0 ppm

Conform

AOAC 986.15, 18th

Lead

<1.0 ppm

Conform

AOAC 986.15, 18th

Mercury

<0.5 ppm

Conform

AOAC 971.21, 18th

Pesticide Residue

666

<0.2ppm

Conform

GB/T5009.19-1996

DDT

<0.2ppm

Conform

GB/T5009.19-1996

Microbiology

Total Plate Count

<1,000cfu/g

11cfu/g

AOAC 990.12, 18th

Total Yeast & Mold

<100cfu/g

3cfu/g

FDA (BAM) Chapter 18, 8th Ed.

E. Coli

Negative

Negative

AOAC 997.11, 18th

Salmonella

Negative

Negative

FDA (BAM) Chapter 5, 8th Ed.

4-product function

1.This product is mainly effect on the central nervous, cardiovascular system, muscle;

2.It is anti-bacterial,and have to lower the body temperature;

3.Recently the studies have also found that it has the following pharmacological effects:

4.It is used to prevent radiation,anti-hydatid,anti-inflammatory and analgesic;

5.It is inhibition of cellular and humoral immunity.

6.It is anti-psoriasis and anti-tumor.

Packing &Storage Condition

12

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