Pure Extract Of Peganum Harmala

1-product details

Detailed Product Description

Product name: Harmine

Source:Peganum harmala L.

Specification:98%

Used Part:Seed

CAS NO. :442-51-3
Molar mass:212.2472

Melting range:262-264°C

Flash Point(°C):139.7°

Appearance:White powder

Flavor: Characteristic taste

Particle Size:80% pass through 80 mesh sieve

Test mothed: HPLC

Molecular formula:C13H12N2O
Extract Solvent: Ethanol & Water

Solubility: Solubility in Methanol. Water-insoluble

Usage: Pharmaceuticals, healthcares,and cosmetics

2-product description

Harmine, and plants containing significant amounts of harmine and other harmala alkaloids are generally not considered safe treatments for depression within the medical community. This bias however is primarily built on previous decades of experience with pharmaceutical non-specific MAOIs that block both MAO-A and MAO-B. Inhibiting MAO-A or MAO-B (in high enough doses) while consuming foods rich in tyramine, e.g. cheese, can cause tyramine, ordinarily metabolized by these enzymes, to accumulate to dangerous levels. This can cause a potentially fatal hypertensive crisis. Because harmine reversibly and selectively inhibits MAO-A and does not degrade MAO-B, MAO-B remains free to metabolize tyramine in the digestive tract. Consequently, the harmala alkaloids (including harmine) are unlikely to elicit tyramine-mediated hypertensive crisis, and a special diet does not need to be so strictly adhered to. Nonetheless, due to the reduction of the levels of tyramine degrading compounds in the gut, it is still not advisable to eat excessively large amounts of tyramine-rich food products.[8] The reversibility and MAO-A selectivity of harmala alkaloids do not, however, prevent potentially fatal interactions with common medications such as antihistamines, most antidepressants, many stimulants, common migraine medications, some herbs, decongestants, expectorants, and common cough and cold medications.

3-product analysis

Item	Specification	Result	Method
BasicProduct Information
Product name	pure extract of peganum harmala
Part of the Plant	seed	Conform	/
Country of Origin	China	Conform	/
Organoleptic Data
Appearance	Fine powder	Conform	NLS-QCS-1008
Color	white powder	Conform	GB/T 5492-2008
Odor& Taste	Characteristic	Conform	GB/T 5492-2008
Process Data
Solvent(s) Used	Water and ethyl alcohol	Conform	/
Extract ration	/	Conform
Content	Paeoniflorin≥98%	98.19
Drying Method	Spray drying	Conform	/
Excipient	Maltodextrin	Conform	/
Physical Characteristics
Particle Size (80 mesh)	98.0%pass 80mesh	Conform	GB/T 5507-2008
Moisture	<5.0%	2.8%	GB/T 14769-1993
Ash Content	<4.0%	1.5%	AOAC 942.05, 18th
Solvent Residue	Eur. Pharm	Conform	NLS-QCS-1007
Heavy Metals
Total Heavy Metals	<10 ppm	Conform	USP <231>, method II
Arsenic	<1.0 ppm	Conform	AOAC 986.15, 18th
Lead	<1.0 ppm	Conform	AOAC 986.15, 18th
Mercury	<0.5 ppm	Conform	AOAC 971.21, 18th
Pesticide Residue
666	<0.2ppm	Conform	GB/T5009.19-1996
DDT	<0.2ppm	Conform	GB/T5009.19-1996
Microbiology
Total Plate Count	<1,000cfu/g	11cfu/g	AOAC 990.12, 18th
Total Yeast & Mold	<100cfu/g	3cfu/g	FDA (BAM) Chapter 18, 8th Ed.
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

4-product function

1.This product is mainly effect on the central nervous, cardiovascular system, muscle;

2.It is anti-bacterial,and have to lower the body temperature;

3.Recently the studies have also found that it has the following pharmacological effects:

4.It is used to prevent radiation,anti-hydatid,anti-inflammatory and analgesic;

5.It is inhibition of cellular and humoral immunity.

6.It is anti-psoriasis and anti-tumor.

Packing &Storage Condition

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Pure Extract Of Peganum Harmala

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