Phloridzin

Phloridzin

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Product Details

1-product details

Product name:Apple peel extract

Extract source:Malus pumila Mill.

Specification:98%

Active ingredient: Phloridzin

Used Part:peel

CAS NO. : 60-81-1

Molecular formula C15H14O5

Molecular weight:274.27

Appearance:white Powder

Flavor: Characteristic taste

Particle Size:80% pass through 80 mesh sieve

Test mothed: HPLC

Extract Solvent: Ethanol & Water

Solubility: Soluble in water, ethanol

Usage: Pharmaceuticals, healthcares,and cosmetics

2-product description

Phloridzin is the specific and competitive inhibition of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). This property which could be useful in the management of postprandial hyperglycemia in diabetes and related disorders. Phloridzin is one of the dihydrochalcones typically contained in apples and in apple-derived products. The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats. As a well-known consequence of becoming diabetic, urine volume and water intake were significantly increased. Administration of phloridzin reduced urine volume and water intake in a dose-dependent manner. Phloretin decreases of food consumption, as well as a marked lowering in the weight. In conclusion, this compound could be proposed as an antihyperglycemic and antihyperlipidemic agent in diabetes and potential therapeutic in obesity

3-product analysis

Item

  Specification

  Result

  Method

BasicProduct Information

Product name

phloridzin



Part of the Plant

peel

Conform

/

Country of Origin

China

Conform

/

Organoleptic Data

Appearance

Fine powder

Conform

NLS-QCS-1008

Color

white powder

Conform

GB/T 5492-2008

Odor& Taste

Characteristic

Conform

GB/T 5492-2008

Process Data

Solvent(s) Used

Water and ethyl alcohol

Conform

/

Extract ration

/

Conform


Content

Paeoniflorin98%

98.17


Drying Method

Spray drying

Conform

/

Excipient

Maltodextrin 

Conform

/

Physical Characteristics

Particle Size (80 mesh)

98.0%pass 80mesh

Conform

GB/T 5507-2008

Moisture

<5.0%

2.8%

GB/T 14769-1993

Ash Content

<4.0%

1.2%

AOAC 942.05, 18th

Solvent Residue

Eur. Pharm

Conform

NLS-QCS-1007

Heavy Metals

Total Heavy Metals

<10 ppm

Conform

USP <231>, method II

Arsenic

<1.0 ppm

Conform

AOAC 986.15, 18th

Lead

<1.0 ppm

Conform

AOAC 986.15, 18th

Mercury

<0.5 ppm

Conform

AOAC 971.21, 18th

Pesticide Residue

666

<0.2ppm

Conform

GB/T5009.19-1996

DDT

<0.2ppm

Conform

GB/T5009.19-1996

Microbiology

Total Plate Count

<1,000cfu/g

19cfu/g

AOAC 990.12, 18th

Total Yeast & Mold

<100cfu/g

3cfu/g

FDA (BAM) Chapter 18, 8th Ed.

E. Coli

Negative

Negative

AOAC 997.11, 18th

Salmonella

Negative

Negative

FDA (BAM) Chapter 5, 8th Ed.

4-product function

1.Phloridzin can be used to treat diabetes. It can inhibit the renal proximal tubule reabsorption of glucose, urinary glucose excretion increased, thereby reducing the level of blood glucose and serum insulin levels are not affected

2.Phloridzin can be used to whitening and acne treatment. Phlorizin can prevent the entry of glucose into epidermal cells, thereby slowing the secretion of sebum to help prevent the occurrence of acne. Tyrosinase is the major rate-limiting enzyme of the melanin biosynthesis, phlorizin through to inhibit tyrosinase to achieve whitening

3.Reduce the number of atherosclerotic lesions in arteries, the amount of cholesterol produced in the liver and uric acid content in the blood

4.Slow the growth of cancer cells and tumors and promote cancer cell death. Prevent skin, breast and colon cancer, and lower the risk of colon and lung cancer; Effect against external aging by promoting the health of skin cells and rejuvenation. Effect the Internal aging by promoting organ health, destroying the free radicals and strengthening fibers;

 

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