Betulin

Betulin

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Product Details

1-product details

Product name:Birch Bark Extract

Extract source: Betula Platyphylla L

Specification: Betulin 70%, 80%, 90%, 98%

Active ingredient:Betulin

Used Part:bark
Specification: 98%

CAS NO. : 473-98-3

Molar mass: 442.7

Appearance:White Powder

Flavor: Characteristic taste

Particle Size:80% pass through 80 mesh sieve

Test mothed: HPLC

Molecular formula:C30H50O2

Extract Solvent: Ethanol & Water

Solubility: Not Soluble in water, lightly soluble in ethanol

Usage: Pharmaceuticals, healthcares,and cosmetics

2-product description

Betulin, a non-bioactive precursor of betulinic acid, is also found in the bark of the Betula alba (white birch) tree at concentrations of up to 25%. The tree is fast-growing and abundant in North America and Europe. The raw material is readily available in large quantities since birch bark is considered a waste product in the pulp and paper, and furniture manufacturing industries.

Betulin (lup-20(29)-ene-3β,28-diol) is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees and forms up to 30% of the dry weight of the extractive.The purpose of the compound in the bark is not known. It can be converted to betulinic acid (the alcohol group replaced by a carboxylic acid group), which is biologically more active than betulin itself.

 

3-product analysis

Item

  Specification

  Result

  Method

BasicProduct Information

Product name

betulin



Part of the Plant

bark

Conform

/

Country of Origin

China

Conform

/

Organoleptic Data

Appearance

Fine powder

Conform

NLS-QCS-1008

Color

White powder

Conform

GB/T 5492-2008

Odor& Taste

Characteristic

Conform

GB/T 5492-2008

Process Data

Solvent(s) Used

Water and ethyl alcohol

Conform

/

Extract ration

/

Conform


Content

Paeoniflorin98%

98.19


Drying Method

Spray drying

Conform

/

Excipient

Maltodextrin 

Conform

/

Physical Characteristics

Particle Size (80 mesh)

98.0%pass 80mesh

Conform

GB/T 5507-2008

Moisture

<5.0%

2.7%

GB/T 14769-1993

Ash Content

<4.0%

1.4%

AOAC 942.05, 18th

Solvent Residue

Eur. Pharm

Conform

NLS-QCS-1007

Heavy Metals

Total Heavy Metals

<10 ppm

Conform

USP <231>, method II

Arsenic

<1.0 ppm

Conform

AOAC 986.15, 18th

Lead

<1.0 ppm

Conform

AOAC 986.15, 18th

Mercury

<0.5 ppm

Conform

AOAC 971.21, 18th

Pesticide Residue

666

<0.2ppm

Conform

GB/T5009.19-1996

DDT

<0.2ppm

Conform

GB/T5009.19-1996

Microbiology

Total Plate Count

<1,000cfu/g

17cfu/g

AOAC 990.12, 18th

Total Yeast & Mold

<100cfu/g

3cfu/g

FDA (BAM) Chapter 18, 8th Ed.

E. Coli

Negative

Negative

AOAC 997.11, 18th

Salmonella

Negative

Negative

FDA (BAM) Chapter 5, 8th Ed.

4-product function

Treatment of liver diseases is directed, mainly, to protecting cells of the liver from the damages caused by different chemical substances. Together with the radiation therapy and the surgery, in the therapy of the tumor pathology, the important component of treatment and rehabilitation of patients appears to be application of medicinal plants. The unique biological activity of the substances of those isolated by white part of birch bark contributes to the decrease of toxic action of chemo- and radiation therapy on the organism

The antioxidant activity of betuline is connected with its direct effect on the ferments of the antioxidant protection, whose basic functional role consists of the decomposition of organic peroxides, first of all - peroxides of lipids, which play paramount role in the disturbance of the normal structure of biological membranes. Substances forming betulin possess the high gepatoprotektornoy and detoxifying activity, inducing the ferments of the rendering safe system of the liver, it normalizes bile secretion, reduces cholesterol level in the blood

3.Betulin contains betulinic acid, which possesses a wide spectrum of biological and pharmacological activities. Betulinic acid has antimalarial and anti-inflammatory activities. Betulinic acid and its derivatives have especially shown anti-HIV activity and cytotoxicity against a variety of tumor cell lines comparable to some clinically used drugs. A new mechanism of action has been confirmed for some of the most promising anti-HIV derivatives, which makes them potentially useful additives to the current anti-HIV therapy. Betulinic acid is specifically cytotoxic to several tumor cell lines by inducing apoptosis in cells. Moreover, it is non-toxic up to 500 mg/kg body weight in mice. The literature concerning derivatization of betulin for structure-activity relationship (SAR) studies and its pharmacological properties is reviewed.

05 Saw Palmetto Extract

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