Product name:Birch Bark Extract
Extract source: Betula Platyphylla L
Specification: Betulin 70%, 80%, 90%, 98%
CAS NO. : 473-98-3
Molar mass: 442.7
Flavor: Characteristic taste
Particle Size:80% pass through 80 mesh sieve
Test mothed: HPLC
Extract Solvent: Ethanol & Water
Solubility: Not Soluble in water, lightly soluble in ethanol
Usage: Pharmaceuticals, healthcares,and cosmetics
Betulin, a non-bioactive precursor of betulinic acid, is also found in the bark of the Betula alba (white birch) tree at concentrations of up to 25%. The tree is fast-growing and abundant in North America and Europe. The raw material is readily available in large quantities since birch bark is considered a waste product in the pulp and paper, and furniture manufacturing industries.
Betulin (lup-20(29)-ene-3β,28-diol) is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees and forms up to 30% of the dry weight of the extractive.The purpose of the compound in the bark is not known. It can be converted to betulinic acid (the alcohol group replaced by a carboxylic acid group), which is biologically more active than betulin itself.
Part of the Plant
Country of Origin
Water and ethyl alcohol
Particle Size (80 mesh)
AOAC 942.05, 18th
Total Heavy Metals
USP <231>, method II
AOAC 986.15, 18th
AOAC 986.15, 18th
AOAC 971.21, 18th
Total Plate Count
AOAC 990.12, 18th
Total Yeast & Mold
FDA (BAM) Chapter 18, 8th Ed.
AOAC 997.11, 18th
FDA (BAM) Chapter 5, 8th Ed.
Treatment of liver diseases is directed, mainly, to protecting cells of the liver from the damages caused by different chemical substances. Together with the radiation therapy and the surgery, in the therapy of the tumor pathology, the important component of treatment and rehabilitation of patients appears to be application of medicinal plants. The unique biological activity of the substances of those isolated by white part of birch bark contributes to the decrease of toxic action of chemo- and radiation therapy on the organism
The antioxidant activity of betuline is connected with its direct effect on the ferments of the antioxidant protection, whose basic functional role consists of the decomposition of organic peroxides, first of all - peroxides of lipids, which play paramount role in the disturbance of the normal structure of biological membranes. Substances forming betulin possess the high gepatoprotektornoy and detoxifying activity, inducing the ferments of the rendering safe system of the liver, it normalizes bile secretion, reduces cholesterol level in the blood
3.Betulin contains betulinic acid, which possesses a wide spectrum of biological and pharmacological activities. Betulinic acid has antimalarial and anti-inflammatory activities. Betulinic acid and its derivatives have especially shown anti-HIV activity and cytotoxicity against a variety of tumor cell lines comparable to some clinically used drugs. A new mechanism of action has been confirmed for some of the most promising anti-HIV derivatives, which makes them potentially useful additives to the current anti-HIV therapy. Betulinic acid is specifically cytotoxic to several tumor cell lines by inducing apoptosis in cells. Moreover, it is non-toxic up to 500 mg/kg body weight in mice. The literature concerning derivatization of betulin for structure-activity relationship (SAR) studies and its pharmacological properties is reviewed.
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