472-15-1

472-15-1

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Product Details

1-product details

Product name:Betula alba L bark extract

Active ingredient:Betulinic acid

Used Part:bark
Specification: 98%

CAS NO. : 472-15-1

Appearance:White Powder

Flavor: Characteristic taste

Particle Size:80% pass through 80 mesh sieve

Test mothed: HPLC

Molecular formula:C30H48O3

Molecular Weight : 456.71

Extract Solvent: Ethanol & Water

Solubility: Not Soluble in water, lightly soluble in ethanol

Usage: Pharmaceuticals, healthcares,and cosmetics

2-product description

Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase.It is found in the bark of several species of plants, principally the white birch (Betula pubescens) from which it gets its name, but also the ber tree (Ziziphus mauritiana), selfheal (Prunella vulgaris), the tropical carnivorous plants Triphyophyllum peltatum and Ancistrocladus heyneanus, Diospyros leucomelas, a member of the persimmon family, Tetracera boiviniana, the jambul (Syzygium formosanum),flowering quince (Chaenomeles sinensis), rosemary, and Pulsatilla chinensis

3-product analysis

Item

  Specification

  Result

  Method

BasicProduct Information

Product name

472-15-1



Part of the Plant

bark

Conform

/

Country of Origin

China

Conform

/

Organoleptic Data

Appearance

Fine powder

Conform

NLS-QCS-1008

Color

White powder

Conform

GB/T 5492-2008

Odor& Taste

Characteristic

Conform

GB/T 5492-2008

Process Data

Solvent(s) Used

Water and ethyl alcohol

Conform

/

Extract ration

/

Conform


Content

Paeoniflorin98%

98.18


Drying Method

Spray drying

Conform

/

Excipient

Maltodextrin 

Conform

/

Physical Characteristics

Particle Size (80 mesh)

98.0%pass 80mesh

Conform

GB/T 5507-2008

Moisture

<5.0%

2.8%

GB/T 14769-1993

Ash Content

<4.0%

1.5%

AOAC 942.05, 18th

Solvent Residue

Eur. Pharm

Conform

NLS-QCS-1007

Heavy Metals

Total Heavy Metals

<10 ppm

Conform

USP <231>, method II

Arsenic

<1.0 ppm

Conform

AOAC 986.15, 18th

Lead

<1.0 ppm

Conform

AOAC 986.15, 18th

Mercury

<0.5 ppm

Conform

AOAC 971.21, 18th

Pesticide Residue

666

<0.2ppm

Conform

GB/T5009.19-1996

DDT

<0.2ppm

Conform

GB/T5009.19-1996

Microbiology

Total Plate Count

<1,000cfu/g

18cfu/g

AOAC 990.12, 18th

Total Yeast & Mold

<100cfu/g

4cfu/g

FDA (BAM) Chapter 18, 8th Ed.

E. Coli

Negative

Negative

AOAC 997.11, 18th

Salmonella

Negative

Negative

FDA (BAM) Chapter 5, 8th Ed.

4-product function

1.Anti-tumor, anti-HIV agent which induces apoptosis via activation of caspases.

2.The potential of betulinic acid was tested using three human melanoma cell lines, MEL-1, -2, -3, and -4. The growth of all of the cell lines was inhibited significantly by treatment with betulinic acid.

3.Betulinic acid seems to work by inducing (programmed cell death) in cancer cells

4.Betulinic acid has also been found to retard the progression of HIV 1 infection, which eventually leads to , by preventing the formation of syncytia (cellular aggregates).

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